Formulation and evaluation of solid self micro emulsifying drug delivery system using aerosil 200 as solid carrier
نویسندگان
چکیده
منابع مشابه
Solid Sirolimus Self-microemulsifying Drug Delivery System: Development and Evaluation of Tablets with Sustained Release Property
The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...
متن کاملSolid Sirolimus Self-microemulsifying Drug Delivery System: Development and Evaluation of Tablets with Sustained Release Property
The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...
متن کاملFormulation and Characterization of Novel Self Micro Emulsifying Drug Delivery System of Glimepiride
The purpose of preparing Self microemulsifying drug delivery system in this work is to enhance the solubility and oral bioavailability of poorly water soluble drug, Glimepiride. SMEDDS are the isotropic mixture of surfactant, co-surfactant and oil incorporated with drug. In the aqueous media, gastro intestinal motility emulsification takes place. Glimepiride was undergone solubility studies in ...
متن کاملDesign and Hepatoprotective Evaluation of Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin Solid Dispersion and Self-Micro Emulsifying Drug Delivery Systems
Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin are widely used drugs for the treatment of hepatitis C virus, have poor bioavailability due to their low aqueous solubility that limits their dissolution rates. To overcome these limitations solid dispersions (SDs) and self-microemulsifing drug delivery systems (SMEDDS) were prepared in an attempt to improve their release profile. SDs were pre...
متن کاملDevelopment and Evaluation of Liquid and Solid Self-Emulsifying Drug Delivery Systems for Atorvastatin.
The objective of this work was to design and characterize liquid and solid self-emulsifying drug delivery systems (SEDDS) for poorly soluble atorvastatin. To optimize the composition of liquid atorvastatin-SEDDS, solubility tests, pseudoternary phase diagrams, emulsification studies and other in vitro examinations (thermodynamic stability, droplet size and zeta potential analysis) were performe...
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ژورنال
عنوان ژورنال: International Current Pharmaceutical Journal
سال: 2012
ISSN: 2224-9486
DOI: 10.3329/icpj.v1i12.12451